Another side effect is a slight reduction in fat-soluble vitamins, generally not The European Multicentre Orlistat Group conducted a double-blind study in which
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Sibutramine, which was approved in Europe in 1999, was the most promising weight loss drug and was considered a completely safe medicine. However, with every year of Sibutramine use in the clinical practice of obesity treatment, more and more evidence has been accumulating that the drug increases the risk of cardiovascular pathologies.
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